gastroplustm version 9.8.3 (Simulations Plus Inc)
90
Structured Review
Simulations Plus Inc
gastroplustm version 9.8.3
Gastroplustm Version 9.8.3, supplied by Simulations Plus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gastroplustm+version+9%2E8%2E3/gastroplustm+software/pm40274028-75-7-10
Average 90 stars, based on 1 article reviews
Gastroplustm Version 9.8.3, supplied by Simulations Plus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gastroplustm+version+9%2E8%2E3/gastroplustm+software/pm40274028-75-7-10
Average 90 stars, based on 1 article reviews
gastroplustm version 9.8.3 - by Bioz Stars,
2026-09
90/100 stars
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other:Article Title: Rat-to-human PBPK model of U-47700: Unveiling pharmacokinetic risks of a synthetic opioid through interspecies extrapolation. Article Snippet: U-47700, a synthetic μ-opioid receptor agonist and emerging new psychoactive substance, poses critical public health risks due to its high abuse liability and fatal overdose potential.. Ethical barriers prohibit clinical pharmacokinetic studies of such controlled substances, necessitating alternative approaches.. Here, we developed the first physiologically based pharmacokinetic (PBPK) model for U-47700 by integrating in vitro experiments—including Caco-2 permeability, tissue-plasma partitioning, plasma protein binding, and human liver microsomal clearance. |